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Trilostane

Trilostane, sold under the brand names Modrenal and Vetoryl among others, is a medication which has been used in the treatment of Cushing's syndrome, Conn's syndrome, and postmenopausal breast cancer in humans For use in: dogs. Indicated for the treatment of pituitary-dependent hyperadrenocorticism in dogs and the treatment of hyperadrenocorticism due to adrenocortical tumor in dogs. Active (s)/Ingredient (s): Trilostane. Pack size (s): 30 capsules. Documents: Package insert get_app SDS get_app. Important safety information Trilostane (Vetoryl) is indicated for the treatment of pituitary-dependant hyperadrenocorticism and treatment of hyperadrenocorticism due to adrenocortical tumors in dogs

Trilostane is a synthetic enzyme inhibiting drug that is used to treat Cushing's disease in dogs and cats. Trilostane decreases the production of excessive cortisol hormone by the adrenal gland. This disease is not cured by trilostane but can be managed successfully Trilostane is a steroid analogue which blocks the production of cortisol, a steroid hormone that is overproduced in dogs with Cushing's disease. It comes in a capsule form that is given to dogs by mouth Trilostane (4α, 5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone In 2001, trilostane, a synthetic steroid analogue, was licensed in the United Kingdom for treating canine pituitary-and adrenal-dependent hyperadrenocorticism. Trilostane is currently undergoing Food and Drug Administration (FDA) review for the same purposes in the United States. In this article, I briefly review the diagnosis and treatment of.

Trilostane - Wikipedi

Vetoryl® Capsules (trilostane

  1. The manufacturer recommends starting trilostane therapy at a dose of 2.2 - 6.7 mg/kg (1 - 3 mg/lb) once daily with food (Vetoryl® package insert)
  2. How to use Trilostane (Bulk) 100 % Powder. Consult your pharmacist or physician. Consult your pharmacist or physician. Call your doctor for medical advice about side effects. You may report side.
  3. Trilostane is a competitive inhibitor of 3-β-hydroxysteroid dehydrogenase. This drug has been used in an attempt to block endogenous cortisol production by the adrenal gland, and has been demonstrated to reverse both the clinical signs and abnormal endocrinologic test results in one series of equine Cushing's disease cases
  4. Trilostane is an inhibitor of 3 beta-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. It was withdrawn from the United States market in April 1994
  5. Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol

Trilostane, Vetoryl - Pet, Dog and Cat Medication and

  1. Trilostane Compounded is used to treat dogs with hyperadrenocorticism, also known as Cushing's disease. Compounding is beneficial in instances where a specific dosage is unavailable or in different forms to make it easier to dose your pet. Trilostane Compounded requires a prescription from your veterinarian
  2. Trilostane: A Therapeutic Alternative for Canine Cushing's Disease. Trilostane (4-alpha, 5-alpha-epoxy-17-betahydroxy- 3-oxoandrostane-2-alpha-carbonitrile) is a synthetic steroid analogue. It is a competitive inhibitor of 3- beta-hydroxysteroid dehydrogenase, an enzyme that catalyzes several vital steps in the synthesis of cortisol from.
  3. Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase (3-β-HSD or delta 5-delta 4-isomerase), an essential enzyme for the biosynthesis of all classes of hormonal steroids
  4. Trilostane Compounded oral liquid is an oil-based preparation. Trilostane is an adrenal steroid synthesis inhibitor that may be prescribed for hyperadrenocorticism (Cushing's Disease) or other adrenal imbalances. Trilostane Compounded oral liquid is made specifically for your pet. Precaution
  5. Trilostane is a well-tolerated option to treat Cushing's disease, but it requires close monitoring, and it can be expensive. It's important to contact your vet right away if you notice any weakness, appetite changes, vomiting, or diarrhea — the medication may need to be adjusted or stopped. Over time, you may start to notice some signs of.
  6. Trilostane - The Good and the Bad - WSAVA 2014 Congress - VIN. The standard medical treatment for HAC (PDH and ATH) dogs has long been mitotane. Mitotane leads to selective necrosis of the adrenal cortex, which may be partially or completely destroyed, depending on the treatment protocol. The efficacy of mitotane is favourable and more than 80%.
  7. Trilostane may also have an effect on the intracellular glucocorticoid receptors; in rats it was shown that glucocorticoid receptor mRNA were significantly decreased by trilostane. After absorption, trilostane has to be converted to active metabolites, such as ketotrilostane in the liver, a process which has not been thoroughly studied in dogs

Vetoryl (Trilostane) is a competitive inhibitor of the enzyme 3-beta-hydroxysteroid dehydrogenase used in dogs for the treatment of pituitary dependent Cushing's Disease and Cushing's Disease due to adrenocortical tumors. It may be necessary to wait at least one month after discontinuing Lysodren before starting treatment with Vetoryl Trilostane (WIN 24540) is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. Trilostane treatment results in a significant decline in basal plasma cortisol concentrations in dogs

Trilostane for Dogs and Cats - Wedgewood Pharmac

Trilostane (4α, 5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone. This inhibition blocks production of glucocorticoids and to a lesser extent. The trilostane in Vetoryl controls the overproduction of cortisol, and thus reduces the clinical signs of Cushing's. This allows your dog to live a relatively normal life. Vetoryl allows you to treat your dog's Cushing's Disease with once daily dosing. Directions. Be sure to follow your veterinarian's instruction regarding the proper doses of. Specifically, trilostane competitively inhibits 3 Beta-hydroxysteroid dehydrogenase, which is the enzyme responsible for converting pregnenolone to progesterone in the adrenal cortex. This leads to a decrease in production of cortisol as well as, to a lesser extent, aldosterone and sex hormones Trilostane is an adrenocortical suppressant used to treat Cushing's disease in dogs. Consult your veterinarian. This is a compounded medication specifically made for your pet based on a prescription from your licensed veterinarian. Compounded medications are not returnable

Trilostane for Dogs Great Pet Car

Vetoryl (Trilostane) is an effective drug that treats Cushing's Disease in dogs. Find it at EntirelyPets Rx. Free Shipping over $49 Trilostane may decrease testosterone and progesterone synthesis. Women who are pregnant or are intending to become pregnant should avoid handling the capsules. The content of the capsules may cause skin and eye irritation and sensitisation. Do not divide or open capsules. In the event of accidental breakage of the capsules and contact of the. Trilostane selectively and reversibly inhibits the enzyme system 3 beta hydroxysteroid isomerase, thus blocking the production of cortisol, corticosterone and aldosterone. When used to treat hyperadrenocorticism, it reduces the production of glucocorticoid and mineralocorticoid steroids in the adrenal cortex Trilostane is a treatment for dogs with Cushing's Disease. Dogs with Cushings exhibit symptoms including: Lethargy. Excessive urination. Excessive thirst/hunger. Hair loss. Many of these symptoms are mistaken for old age and other age or breed related causes. Once diagnosed your dog can start using Trilostane to control symptoms and stop the. Trilostane (Vetoryl®) Dosing and Monitoring* Treatment of Canine Hyperadrenocorticism Day 1 Start trilostane treatment. Administer 2 mg/kg in morning or 1 mg/kg twice daily with food. Observe for lethargy, decreased appetite, vomiting or diarrhea. If adverse reactions observed discontinue trilostane and evaluate patient. Day 10-1

Vetoryl (Trilostane) 30 mg (30 capsules) is an effective drug that treats Cushing's Disease in dogs. Find it at EntirelyPets Rx Vetoryl (Trilostane) is used to treat dogs with hyperadrenocorticism (Cushing's Disease). It is a competitive inhibitor of the enzyme 3-beta-hydroxysteroid dehydrogenase used in dogs for the treatment of pituitary dependent Cushing's Disease and Cushing's Disease due to adrenocortical tumors

Vetoryl (trilostane) Capsules for Animal Use - Drugs

Trilostane: A therapeutic consideration for canine

Trilostane may decrease testosterone synthesis and has anti-progesterone properties. Women who are pregnant or are intending to become pregnant should avoid handling the capsules. Wash hands with soap and water following accidental exposure and after use Trilostane is recommended for dogs that do not tolerate Lysodren well. It is an effective—albeit a more expensive—alternative for Cushings. Although dogs that have severe side effects with Lysodren might not experience the same ones with Trilostane, this does not mean that Trilostane is side effect free

Trilostane (4α,5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone. This inhibition blocks production of glucocorticoids and to a lesser extent. Trilostane is a synthetic, hormonally inactive steroid analogue, which is a competitive inhibitor of the 3-beta-hydroxysteroid dehydrogenase system. Pharmacodynamics. Trilostane blocks synthesis of adrenal steroids, including cortisol and aldosterone. 8-14 It is rapidly absorbed orally (peak concentrations within 1.5 H), although suppression of. Trilostane, sold under the brand names Modrenal and Vetoryl among others, is a medication which has been used in the treatment of Cushing's syndrome, Conn's syndrome, and postmenopausal breast cancer in humans. It was withdrawn for use in humans in the United States in the 1990s but was subsequentl the pre-trilostane cor e the dog is clinically genic hypoadrenoco try screen, UA). has co-morbidity such as dia Con cur adm or, if dosing > > 4 ug/dL mol/L e history & perform an ulation test ACTH stimulation test Clinically W Continue trilostane at Return to D peradre e Cortiso ATIONS history and do a thor o to consider is the o tisol level. Trilostane Chemical Properties,Uses,Production treatment of Cushing's syndrome Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome and primary hyperaldosteronism. These are both disorders where excess amounts of corticosteroid hormones are produced in the body

Trilostane (also commonly known as Vetoryl) is a medication used commonly in the treatment of Cushing's Disease in dogs. Trilostane works in dogs by inhibiting cortisol production in the adrenal gland. It is a prescription medication and requires you to visit the vet before use. Trilostane dosage for dog Vetoryl Capsules are used for the treatment of pituitary-dependent hyperadrenocorticism (Cushing's syndrome) and hyperadrenocorticism due to adrenocortical tumor in dogs. Vetoryl Capsules contain trilostane. The starting dose for the treatment of hyperadrenocorticism in dogs is 1.0-3.0 mg/lb (2.2-6.7 mg/kg) once a day Buy Vetoryl (Trilostane) capsules online from Australia's most trusted registered pet pharmacy. Save up to 50% on Vetoryl and get it delivered to your door Australia wide. We stock Vetoryl 10mg, 30mg, 60mg and 120mg capsules

Vetoryl for Dogs Dechra Veterinary - Safe

Trilostane is commonly used in the treatment of dogs with naturally occurring pituitary-dependent hyperadrenocorticism (PDH). Dose recommendations have varied from the manufacturer and the literature. Hypothesis. As body weight increases, dose/kg or dosage/day of trilostane required to control the clinical signs of PDH decreases. Animal Trilostane treatment was intraperitoneally injected at doses of 30 mg/kg and 60 mg/kg, respectively, in two different subgroups of mice for two consecutive weeks. Both doses of trilostane significantly slowed tumor growth compared with DMSO mock-treated controls (p < 0.01; Fig. 5a) in a dose-dependent manner. A higher inhibitory effect was seen. Trilostane is a competitive inhibitor of 3B-hydroxysteroid dehydrogenase (Potts). Personally, I need a translation for what on earth that means! Basically trilostane inhibits an enzyme essential to the synthesis of both glucocorticoids and mineralocorticoids in the adrenal cortex Trilostane (4α,5α-epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile) is an orally active synthetic steroid analogue that selectively inhibits 3 β-hydroxysteroid dehydrogenase in the adrenal cortex, thereby inhibiting the conversion of pregnenolone to progesterone

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Trilostane suppresses SCC within 1 hour of administration and its duration of action in most PDH dogs is 8 hours. CONCLUSIONS AND CLINICAL IMPORTANCE: No single variable or group of variables reliably discriminated A dogs from U dogs during trilostane treatment for PDH. PY - 2020 LA - DA - 2020-07 VL - v. 34 IS - no. 4 SP - pp. 1413-1422 DO. Trilostane is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase. In vitro, the drug inhibits conversion of pregnenolone to progesterone but does not alter conversion of cholesterol to. The trilostane dose varies between dogs and for an individual dog over time, due to differences in physiological state and progression of disease. Therefore, the starting dose is adjusted based on changes in clinical signs, results of the biochemical testin

Trilostane (AX Pharmaceutical Corp): FDA Package Insert

The mean duration of trilostane treatment for 21 PDH dogs studied was 8.6 months (range, 1-25) and dosages at the time of the studies ranged from 0.2 to 6.6 mg/kg PO q12h (mean, 0.91 mg/kg PO q12h). Dogs in the A group had been given trilostane for 3 to 28 months (mean, 13.3 months) and dogs in the U group 1 to 28 months (mean, 7.2 months) Although trilostane and mitotane are the top two medications to treat canine Cushing's disease, other medications are available. For example, ketoconazole, which is an antifungal medication, blocks cortisol production. It is recommended for dogs that either can't tolerate or don't respond to trilostane or mitotane Trilostane(Win 24540; Modrastane) is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome. IC50 value: Target: 3 β-HSD Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase (3-β-HSD or delta 5-delta 4-isomerase), an essential enzyme for the biosynthesis of all classes of hormonal steroids

New lower starting dose for Vetoryl | Vet Times

Vetoryl - FDA prescribing information, side effects and use

Trilostane is a synthetic steroidal enzyme inhibitor that decreases the high levels of cortisol hormone being produced by an overactive adrenal gland (hyperadrenocorticism). Why Trilostane Is Prescribed in Veterinary Medicine. Because hyperadrenocorticism is the primary sign of Cushing's Disease, trilostane is most often used to treat the. Vetoryl Capsules are used for the treatment of pituitary-dependent hyperadrenocorticism (Cushing's syndrome) and hyperadrenocorticism due to adrenocortical tumor in dogs. Vetoryl Capsules contain trilostane, an adrenocortical suppressant. The starting dose for the treatment of hyperadrenocorticism in dogs is 1.0-3.0 mg/lb (2.2-6.7 mg/kg) once a day. Vetoryl should be given with food. Trilostane The Food and Drug Administration (FDA) is amending the animal drug regulations to reflect the original approval of a new animal drug application (NADA) filed by Dechra, Ltd. The NADA provides for the veterinary prescription use of trilostane capsules in dogs for treatment of pituitary-dependent.. Trilostane inhibits the enzyme system involved in the synthesis of cortisol and aldosterone. It has become widely used to treat dogs with hyperadrenocorticism, but dosage regimens are still evolving. Thomas Strand/Getty Images. Currently in the United States, the manufacturer recommends a dose of 2.2 to 6.7 mg/kg given orally once a day What the Trilostane does is block adrenal hormone from being produced and used by the body. (When Buddy was first diagnosed, he had way too much adrenal hormone and this is what caused the Cushing's symptoms.) However, it's possible to block too much of this hormone

Hyperadrenocorticism in dogs | Vetlexicon Canis from

Specific information on trilostane acute toxicity was not located. One source states that trilostane overdoses would be unlikely to threaten life and no clinical signs would be expected. However, blood pressure, hydration status, and electrolyte balance should be monitored. If the animal is stressed, consider giving exogenous corticosteroids. Trilostane does not require an induction phase as mitotane does. However, small adjustments to the dose of trilostane are often needed early in treatment, and over the life of your dog, other changes may be made based on routine monitoring of blood tests and how well the clinical signs of Cushing's disease are being controlled Equine Equine. We are the nationwide source for livestock veterinary products solely focused on the needs of the practicing veterinarian. Livestock Livestock. Covetrus has a team of dedicated members who specialize in meeting the unique needs of Animal Welfare and Veterinary Teaching Institutions OK, I feel better. Get her to acupuncture sooner than later as any effect that the steroids will have will dissipate immediately after they're stopped. Special diets aren't recommended for Cushings unless there is a concomitant diabetes mellitus. 50#=23kg, so 23mg of trilostane twice daily

Trilostane is indicated for the treatment of pituitary-dependent hyperadrenocorticism in dogs and the treatment of hyperadrenocorticism due to adrenocortical tumor in dogs. Toggle menu Shop 40, 2-4 Picrite Close, Pemulwuy NSW 2145 Australi Definition of trilostane in the Definitions.net dictionary. Meaning of trilostane. What does trilostane mean? Information and translations of trilostane in the most comprehensive dictionary definitions resource on the web Trilostane is an inhibitor of 3??-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome Trilostane is an inhibitor of the 3β- HSDs: 3β- HSD1 and 3β- HSD2 with K i values of 0.10 and 1.60 μM, respectively. 1 Trilsotane has been approved for use in the treatment of Cushing's syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels. 2 Because human 3β- HSD (type 1) is a critical enzyme in the conversion of.

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Trilostane is a fast-acting agent with very few side effects. It is well-tolerated for most cats and dogs, but you need to watch your pets closely after they are medicated. Side effects include but not limited to: loss of appetite, vomiting, diarrhea, lethargy, unstable walk, weakness, heavy panting, muscle pain, excessive drooling Topical polypharmaceuticals for ear disease. Guidelines for responsible antibacterial use. Guidelines on prescribing glucocorticoids. Radiographic contrast agents. Composition of intravenous fluids. Safety and handling of chemotherapeutic agents. Body weight (BW) to body surface area (BSA) conversion tables. Percentage solutions Reproductive Toxicity. Listed as causing: Developmental Toxicity. Developmental Toxicity. Date of Listing: 04/01/1990. Basis for Listing

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The Side Effects of Vetoryl for Dogs With Cushing's Disease? One of the common medications that veterinarians prescribe for dogs with Cushing's disease is called Vetoryl.Its main active ingredient is trilostane, which is a steroidogenesis inhibitor.Sometimes, the medication is sold under other names though trilostane pronunciation with meanings, synonyms, antonyms, translations, sentences and more Which is the right way to pronounce the word perdón in Swedish? paird-o Trilostane . Listed as Causing Reproductive Toxicity. Developmental Effects: 04/01/1990. Basis for Listing: FR. If you have any questions, comments, or concerns about the content of this page, please click here. Contact Us ×. Web Form center. VETORYL Capsules (trilostane) are veterinary-approved for the treatment of hyperadrenocorticism. Active listening and then addressing client concerns or comments are key to successful diagnosis and treatment. Monitoring needs to be shared by the client and veterinary team

Trilostane, Prednisone, and ACTH Stimulation Testing in Dogs with Cushing's Disease My problem patient is Buddy, an 8-year old, male neutered Labrador Retriever weighing 42 kg. Buddy first developed diabetes, which was difficult to control because of insulin resistance Trilostane. Molecular Formula C 20 H 27 NO 3; Average mass 329.433 Da; Monoisotopic mass 329.199097 Da; ChemSpider ID 570949 - 8 of 8 defined stereocentres. More details: Systematic name (4alpha,5alpha,17bet a)-3,17-Dihydroxy-4, 5-epoxyandrost-2-ene-2-carbonitrile. SMILES Vetoryl (trilostane) is the only drug approved by FDA to treat both pituitary- and adrenal-dependent Cushing's in dogs. This prescription drug works by stopping the production of cortisol in the. Trilostane is the drug most commonly used by veterinarians to help with Cushing's disease treatment in cats. Cushing's Disease Can Strike Cats: An overproduction of Cortisol may be the culpri Conclusions: Trilostane caused improvement in clinical signs in horses, without side effects, and a corresponding decrease in cortisol response to TRH administration. Potential relevance: Trilostane may be a useful therapy for the treatment of ECS. Further work comparing the effects of trilostane and pergolide is warranted

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A method of determining Trilostane in a compound mixture comprising effecting a chromatographic separation of said mixture and analysing the eluate from the separation to determine Trilostane. The method characterised in that the chromatographic separation is effected using a chromatographic stationary phase comprised of a cross­linked resin incorporating aromatic groups Buy Trilostane online from WorldOfChemicals. We have the list of top Trilostane suppliers, manufacturers, wholesalers and traders with the best price listed from worldwide

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Trilostane is a competitive inhibitor of 3β-hydroxysteroid dehydrogenase, the enzyme essential for synthesis of Cortisol and all other steroids. Trilostane is reported to be safe and effective in the treatment of pituitary-dependent hyperadrenocorticism (HAC), adrenal-dependent HAC, and alopecia X.. The pharmacokinetics of trilostane and one of its metabolites ketotrilostane are described and characterized in the rat following the separate intravenous administration of trilostane and ketotrilostane. It was noted during these studies that the parent compound and its metabolite undergo metabolic interconversion-trilostane producing ketotrilostane and ketotrilostane generating trilostane. Trilostane is the chemical name for a medication that is being used successfully to treat Canine Cushing's Disease. Worldwide, the only licensed veterinary version of trilostane is manufactured in the U.K. by the Dechra Group under the brand name of Vetoryl

Trilostane is a reversible inhibitor of steroid synthesis and CASE HISTORY this complication has not been reported previously. Clinicians should be aware that trilostane therapy may result in adrenal necrosis but A 10-year-old, male neutered Staffordshire bull terrier weighing 17 kg presented to a that prompt treatment might correct a life. Trilostane is commonly used to treat pituitary-dependent hyperadrenocorticism (PDH) in dogs. There are differing opinions regarding the dose and frequency of trilostane administration in dogs with PDH. Objectives. To compare the efficacy of 2 trilostane protocols in the treatment of dogs with PDH Results of in vitro steroid production experiments with trilostane. Means ± SE. Different letters indicate statistically significant differences among treatments within a given experiment (p < 0.05).(A) In vitro E2 production by fathead minnow ovary tissue exposed to varying concentrations of trilostane for 12 h; 25-hydroxycholesterol (OH-cholesterol) was provided as a substrate Vetoryl/Trilostane is supposed to be given with food, the reason given for this is that it is a fat soluble. But since it is a fat soluble, should it not be enough to give the medicine together with a sufficient amount of fat? I am asking because many veterinarians asks of their clients to fast their dog in ther morning of an ACTH-test 13647-35-3 - KVJXBPDAXMEYOA-CXANFOAXSA-N - Trilostane [USAN:INN:BAN:JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information

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The canine cushings medication Vetoryl contains Trilostane, which is an anti-corticosteroidal, adrenal-suppressant drug. Vetoryl is used for treatment of the clinical signs caused by Cushing's disease. Although it is considered to be a cushings disease dog treatment, it is not a true cure for Cushing's disease in dogs Therefore, trilostane and cyanoketone were powerful competitive inhibitors of the conversion of DHA to 4-androstenedione but were weak non-competitive inhibitors of the conversion of andien-beta to dienone. The selective effects of trilostane and cyanoketone on the 3 beta-HSD-Is involved in the androgen and 16-androstene biosynthetic pathways. keyboard_arrow_right. To control hyperadrenocorticism associated with pituitary-dependent and adrenal-dependent hyperadrenocorticism in dogs. Active (s)/Ingredient (s): Trilostane. Pack size (s): 30. Documents: Pack Insert get_app MSDS get_app. Veterinary Professional Materials