Dicționar dexonline. Definiții, antonime, conjugări, declinări, paradigme pentru postnatal din dicționarele: DEX '09, MDA2, DEX '98, DN, MDN '00, DCR2, NODEX. Postnatal dexamethasone (DEX) increases Functional Residual Capacity (FRC) and respiratory compliance (CRS) in both preterm females and males — Oregon Health & Science University Postnatal dexamethasone (DEX) increases Functional Residual Capacity (FRC) and respiratory compliance (CRS) in both preterm females and male While postnatal dexamethasone (dex) therapy ameliorates bronchopulmonary dysplasia (BPD) in preterm infants, it also increases rates of neuromotor and cognitive abnormalities. In a study by Murphy et al, dex therapy was associated with reduced cerebral cortical gray matter (GM) volumes as compared to untreated infants on volumetric MRI.However, in that study, the impact of BPD was not. Postnatal glucocorticoid administered has been commonly used in premature infants suffering from respiratory distress syndrome to prevent chronic lung disease. However, systemic glucocorticoid administration, predominantly dexamethasone (DEX), is associated with serious adverse effects later in life, including hypertension In order to test the hypothesis that early postnatal exposure to dexamethasone (Dex) influences matrix metalloproteinases (MMP)‐2 and ‐9, as well as their tissue inhibitors (TIMP‐1 and ‐2) in the developing rat lung, newborn rats (3 litters/group) were treated with low Dex (0.1 mg/kg/day, IM), high Dex (0.5 mg/kg/day), or equivalent volumes of saline at 5 days postnatal age (P5), P6.
Early postnatal dexamethasone treatment is widely used for the prevention and treatment of chronic lung disease in premature infants. 1 However, the results of clinical trials have been contradictory as to the effect on short term respiratory status and mortality. 2-11 Recently, follow up studies have raised the possibility that early postnatal dexamethasone treatment may be associated with an adverse effect on subsequent neuromotor function and somatic growth. 1 When rat pups were injected subcutaneously with DEX 25 µg/kg on postnatal day 7 and again on postnatal day 8, we discovered that this agent did not affect hippocampal-dependent memory in freely.. Dex (0.2 mg/kg/day) was injected intramuscularly into the neonatal pig (age: 2 days postnatal) during the first week post-MI. Myocardial scar and left ventricular function were determined by cardiac magnetic resonance (CMR) imaging In contrast, postnatal DEX resulted in a much smaller, albeit significant, induction in CA3 caspase-3 compared with prenatal treatment. Quantitative real-time PCR analysis revealed that prenatal but not postnatal DEX-induced hippocampal cleaved caspase-3 correlated with elevated mRNA of the proapoptotic gene Bad Early DEX treatment resulted in increased infant body weight at postnatal d 56 and 84, co-occurring at the behavioral level with increased time spent in eating solid food, a mobile state, solitary play, and exhibiting tail hair piloerection
. We examined whether maternal melatonin therapy prevents programmed hypertension synergistically induced by prenatal DEX plus postnatal HF in adult offspring. We also examined whether DEX and melatonin causes r The use of postnatal dex to alleviate respiratory disease in premature babies is limited because of the long-term growth retardation of the developing lung and associated neurological defects in children that were exposed to postnatal dex as preterm babies
The use of postnatal dex to alleviate respiratory disease in premature babies is limited because of the associated growth retardation of the developing lung and neurological defects in children that were exposed to postnatal dex as preterm babies. She is looking at the efficacy of these analogs in elevating markers of lung maturation and. Pre- and postnatal corticosteroids are often used in perinatal medicine to improve pulmonary function in preterm infants. To mimic this clinical situation, newborn rats were treated systemically with dexamethasone (Dex), 0.1-0.01 mg/kg/day on days P1-P4. We hypothesized that postnatal Dex may have an impact on alveolarization by interfering with extracellular matrix proteins and cellular. Effect of early postnatal dexamethasone (Dex) administration on lung weight (grams). Rats were administered low (0.1 mg/kg, i.m.) or high (0.5 mg/kg, i.m.) doses of Dex or saline, at 5, 6, and 7. In this study, we characterized the impact of antenatal glucocorticoids and postnatal surfactant on neonatal survival of Erk3 null mice.Methods:In a double crossover design, we administered dexamethasone (dex) or saline to pregnant dams during the saccular stage of lung development, followed by postnatal surfactant or saline via inhalation. Postnatal treatment of 29-day GA fetuses with 0.5 mg/kg of dexamethasone (Dex) iv resulted in a 2- and 22-fold increase in lung α-ENaC mRNA expression compared with saline-treated fetuses after 8 and 16 h, respectively. Lung α-ENaC protein levels in Dex-treated fetuses were also elevated compared with saline-treated counterparts
Dexamethasone induces apoptosis in the developing rat amygdala in an age-, region-, and sex-specific manne Prenatal dexamethasone (DEX) exposure and high-fat (HF) intake are linked to hypertension. We examined whether maternal melatonin therapy prevents programmed hypertension synergistically induced by prenatal DEX plus postnatal HF in adult offspring. We also examined whether DEX and melatonin causes renal programming using next-generation RNA sequencing (NGS) technology postnatál, -ă adj. 1979 Care urmează după naștere v. prenatal (din fr. postnatal; DEX-S
Even though beneficial effects of DEX were seen in the postnatal period (ie, fewer days of ventilator dependence), 43 no differences between the DEX (n = 68) and placebo (n = 74) groups were noted at follow-up in terms of FVC, FEV 1, FEV 1 /FVC, FEF 25-75, peak expiratory flow rate or bronchodilator responsiveness, or respiratory morbidity (ie. prenatal DEX exposure and post-natal HF diet on RAS sig-naling in adipose tissue. We found prenatal GC exposure altered the ACE1/ANG II/AT1R axis, whereas postnatal HF diet negatively impacted the ACE2/ANG-(1-7)/MasR axis. Thus, prenatal DEX exposure and postnatal high-fat diet exerted a synergistic effect on blood pressure elevatio The absence of significant effects of antenatal DEX on either GR or calcyon gene expression in adult PFC suggests the presence of compensatory - and possibly but not necessarily protective - mechanisms acting during the protracted postnatal maturation of the primate PFC [39, 40]. However, it will be important to assess in future studies.
.2 days, irrespective of postnatal diet. Prenatal Dex programmed increased blood pressure in adult offspring, an effect worsened by the postnatal HF diet. Supplementation with high n-3 fatty acids, however, prevented both the Dex and HF-induced increases in blood pressure Despite observing beneficial effects of DEX in the postnatal period (i.e., fewer days of ventilator dependence), no differences were noted at follow-up between DEX (n=68) and placebo (n=74) groups for FVC, FEV 1, FEV 1 /FVC, FEF 25-75, peak expiratory flow rate or bronchodilator responsiveness, or in respiratory morbidity (current asthma. Lasting effects of postnatal Dex treatment have been reported , but these data should be interpreted with caution because Dex has a very different pharmacological profile than corticosterone, and daily treatment also cannot sufficiently mimic a chronic increase in corticosterone secretion. Here, we showed that postnatal glucocorticoid excess.
In contrast, postnatal DEX resulted in a much smaller, albeit significant, induction in CA3 caspase-3 compared with prenatal treatment. Quantitative real-time PCR analysis revealed that prenatal but not postnatal DEX-induced hippocampal cleaved caspase-3 correlated with elevated mRNA of the proapoptotic gene Bad The association of hepatocyte apoptosis with prenatal DEX and postnatal high-fat diet was unknown. The adipocyte hormone leptin is a critical modulator of both acute appetitive state and long-term metabolic health. Leptin was initially described as an adipostatic signal controlling food intake an Hypertension can originate from pre- and post-natal insults. High-fat (HF) diet and prenatal dexamethasone (DEX) exposure are both involved in hypertension of developmental origins. We examined whether postnatal HF diet sex-specifically increases the vulnerability to prenatal DEX exposure-induced programmed hypertension in adult offspring. Additionally, we sought to identify candidate proteins. postnatal alveolar development. Methods: Neonatal lung development in wildtype and HO-1 mutant mice was evaluated by histological and molecular methods. Furthermore, these newborn mice were treated with postnatal dexamethasone (Dex) till postnatal 14 days, and evaluated for lung development Effect of postnatal DEX and oxygen on RAR mRNA expression in rat lung. Rat pups at 12 hours of age were exposed to room air or >95% oxygen for the following 3 days and received either saline or DEX injection at 0, 24, and 48 hours; animals were sacrificed 24 hours after the last injection. All values represent RAR densitometry values normalized.
Vehicle- or DEX-exposed offspring were weaned on postnatal day 21 (PND21) and reared in mixed social groups until 12 weeks old. Twelve males and 12 females were randomly picked up from each group for behavior test at 12 weeks old Postnatal DEX treatment increased mRNA expression of MT1 and MT2, while decreased RORα and RZRβ in the kidney. These changes were prevented by melatonin therapy. Postnatal DEX decreased protein level of MT2 in the kidney, which was attenuated by melatonin therapy. Renal protein level of RORα was higher in DEX+MEL group compared to control. The 3 mg of DEX was administered by intramuscular route every second day from day 70 of pregnancy to parturition and then piglets were supplemented with 2-Ox during 35 days of postnatal life (0.4. dexamethasone (DEX) at different time points during early Dex development will alter expression profiles 10of hypothalamic genes in the adult rats. Rats were treated with DEX at Postnatal Day (PND) 4‐6 differentand the effects of this exposure on gene expression were compared to Furthermore, these newborn mice were treated with postnatal dexamethasone (Dex) till postnatal 14 days, and evaluated for lung development. Compared to wildtype littermates, HO-1 mutant mice.
The association of hepatocyte apoptosis with prenatal DEX and postnatal high-fat diet. was unknown. The adipocyte hormone leptin is a critical modulator of both acute appetitive state and long-term DEX was administered to timed-pregnant rat dams from gestational day 18 until parturition, or postnatal day 4-6. Offspring were sacrificed the day following the last DEX treatment, and tissue was processed for immunohistochemical detection of cleaved caspase-3, a marker for apoptotic cells . Thus, we compared DEX with a less potent GC, hydrocortisone (HC) to explore HC doses that would be clinically effective. Using an animal model we compared and measured lung SP-A level following three different DEX and HC dosing schedules Systematic reviews indicate that treating VLBW infants with corticosteroids, primarily dexamethasone (DEX), in the first few weeks of life significantly decreases the duration of ventilator dependence and the incidence of CLD. 11-13 The beneficial effects of postnatal corticosteroids on the lungs are believed to be related to reduced. Inhaled glucocorticoid treatment during the first 2 yr of life is controversial because this is a period of major structural remodeling of the lung. Rabbits received aerosolized budesonide (Bud; 25..
Development of the blood-brain barrier within the paraventricular nucleus of the hypothalamus: influence of fetal glucocorticoid exces
Side effects of pre-and postnatal GC exposure may develop into chronic conditions with permanent effects on growth, metabolism, cognition, behavior and normal immune functioning. In this study, the effects of prenatal DEX treatment and postnatal GC treatment in the context of CAH were evaluated in a cohort of 265 individuals Glucocorticoid administration to preterm infants is associated with neurodevelopmental disorders. We treated developing rats with dexamethasone (Dex) at 0.05, 0.2, or 0.8 mg/kg, doses below or spanning the range in clinical use, testing the effects of administration during three different stages: gestational days 17-19, postnatal days 1-3 or postnatal days 7-9 tapering doses of DEX and HC in neonatal rats with timing of exposure corresponding developmentally to times these agents are used in clinical practice. A within litter design was used. Intramuscular DEX, HC or saline (VEH-control) were administered to newborn pups on postnatal days (PD) 5 and 6. Neurological development and growt Since the hippocampus contains a high density of glucocorticoid receptors (GCRs), we hypothesized that Dex affects neurogenesis in the hippocampus through inflammatory mediators. Methods . Albino Wistar rat pups first received a single dose of Dex (0.5 mg/kg) on postnatal day 1 (P1) and were sacrificed on P2, P3, P5, and P7
• The two most commonly used sGCs in the prenatal and postnatal periods are Dexamethasone (Dex) and Betamethasone (Beta) . These molecules are very chemically similar (shown below). • While Dex has been shown to decrease the risk of IVH in some studies. 2,3, Dex use has also been implicated in the later development of neurological deficits. glucocorticoid dexamethasone (DEX) in utero accelerates the maturation of cholinergic retinal neurons (Puro, 1983). Moreover, in postnatal rats DEX increases the synthesis of acetylcholine in superior cervical ganglia (Sze et al., 1993) and promotes the development of neonatal brain cholinergic nerve terminals (Za-halka et al., 1993) Wyrwoll et al demonstrated that programmed hyperleptinemia and hypertension, also induced by Dex overexposure in utero, in Wistar rats [Dex administered in the drinking water (0.75 μg/mL) from day 13 of pregnancy until birth], are completely blocked in the offspring by a postnatal diet enriched with ω-3 fatty acids (the majority being long.
of birth was designated as postnatal day 0 (P0), and litters of eight or more pups were included in this study. P0 male offspring of maternally VEH- (VEH-P0, = 6) and DEX-administered n (DEX-P0, n = 6) group were taken from two different litters for each group. Sex determination of the P0 pups was confirmed b The TG-GnRH neurons were examined in intact male and female rats at different postnatal ages, as a marker for GnRH promoter activity. Pregnant females were subcutaneously injected with DEX (0.1 mg/kg) or vehicle daily during gestation days 13-20 to examine the number of GnRH neurons in P0 male offspring
Dexamethasone (Dex) is a common drug in the clinic, and it is an adrenal cortex hormone. It has anti-inflammatory (Dey and Bishayi 2019), anti-immune (May et al. 1990), anti-shock (Akiyama et al. 1984) and stress-relieving effects (Kumari et al. 2019), and it is widely used for the treatment of various clinical diseases.Dex has been reported to treat bacterial meningitis (Jaspan et al. 2010. The typical range of doses for DEX used in rodent research to probe the glucocorticoid system is 1-10 mg/kg [16-19]. In our previous work  we found DEX, 3.0 mg/kg on postnatal day (PND) 7, produced mild deficits in vertical rearings but had no effects on other activity-related variables. We
Prenatal dexamethasone exposure, postnatal development, and adulthood prepulse inhibition and latent inhibition in Wistar rats. Behavioural Brain Research, 2006. Jonas Hauser. Christopher Pryce. Joram Feldon. Download PDF. Download Full PDF Package. This paper. A short summary of this paper Furthermore, T-tubule development in T3+Dex-treated hiPSC-CM after 5 days is less organized than in adult human myocardium and more reminiscent to that found in day 15 to 20 postnatal rat hearts. 17 Hence, future studies are required to establish optimal culture conditions to achieve further T-tubule maturation (eg, longer culture time, tuning. The gonadotropin-releasing hormone (GnRH) neuronal system regulates fertility across vertebrates. Thus, migration and positioning of GnRH neurons in the preoptic area (POA) is crucial for proper development and maturation of the GnRH system. However, prenatal stress and glucocorticoid exposure alters reproductive function and behaviour in the adult offsprings. Furthermore, prenatal. Neonatal rats were administered subcutaneous injections of CIC, DEX or vehicle from postnatal days 1-5 (PND1-PND5). Systemic effects linked to DEX exposure, including reduced body and brain weight, were not observed in CIC treated neonates
Dex decreased galaptin activity and synthesis when administered daily during the critical period of alveolarization (postnatal days 3-13) described by Massaro and coworkers (J Clin Invest 76. KET, DEX, or saline was administrated to mice at postnatal day 7. After the mice were gently separated from their mothers', intraperitoneal single-shot injections were performed carefully. All mice were separated from their mothers and placed in the standard cages (5-6 mice per cage) on day 21
During normal development, MK expression was maximal during the period of alveolarization from postnatal day 5 (PN5) to PN15. DEX treatment of rat pups decreased, and RA treatment increased lung MK expression, whereas concurrent DEX+RA treatment prevented the DEX-induced decrease in MK expression In DEX-treated infants these changes were more pronounced than in HC-treated infants. CONCLUSION: These data suggest that postnatal growth patterns of preterm born infants are affected by CS-treatment, more by DEX than by HC. Effects were observed mainly on growth velocities Representative fields at postnatal day 120 in the groups treated with (D) vehicle, (E) DEX for 2 days and (F) 7 days. Figure 2. Western blot analysis of lamin A/C in the V and prenatal DEX groups of lung tissue at D7 and D120 The objective of this study was to investigate cellular apoptosis in prenatal glucocorticoid overexposure and a postnatal high fat diet in rats. Pregnant Sprague-Dawley rats at gestational days 14 to 21 were administered saline (vehicle) or dexamethasone and weaned onto either a normal fat diet or a high fat diet for 180 days; in total four experimental groups were designated, i.e., vehicle.
Unit 1 - Understanding the Term 'Postnatal Depression' - In this unit you will learn what the term postnatal depression means and start to understand the signs and symptoms of postnatal depression.You will also gain an understanding of the difference between postnatal depression and the baby blues, as well as the possible risk factors for postnatal depression Hypertension can originate from early-life exposure to oxidative stress. As reported, dimethyl fumarate (DMF) activates nuclear factor erythroid-derived 2-related factor 2 (Nrf2) and protects against oxidative stress damage. We examined whether maternal DMF therapy protects adult offspring against hypertension programmed by prenatal dexamethasone (DEX) and postnatal high-fat (HF) diet exposure Int. J. Mol. Sci. 2019, 20, 3957 4 of 13 Figure 2. Immunohistochemical staining of 8-hydroxydeoxyguanosine (8-OHdG) at 16-week-old male o spring kidney. (A) Light micrographs illustrating immunostaining for 8-OHdG in the kidneyexposed to prenatal dexamethasone (DEX), postnatal high-fat diet (HF), and dimethyl fumarate (DMF)
N2 - Myogenesis occurs in both the prenatal and postnatal periods and the prenatal myogenesis is related to the postnatal myogenesis and the incidence of disease later in life. Glucocorticoids used as therapeutic agents for many diseases, but cause adverse effects on muscle homeostasis, including defects in fetal muscle development The ontogenic and hormonal regulation of a sulfotransferase, SULT1B1, was examined. Hepatic RNA was isolated from rats of various ages from 1 to 90 days. The mRNA for SULT1B1 is low for both sexes until a dramatic increase (∼6-fold) occurs between 15 and 30 days of age in male rats. SULT1B1 expression then decreases to half of the maximal level by 90 days of age POSTNATAL - Consultare dictionare pentru limba romana: DEX - Dictionar explicativ, sinonime, antonime, ortografic, arhaisme, regionalisme, etimologic, neologisme. Cautarea se face dupa forma baza sau forma flexionara, cu sau fara diacritic
Therefore, combined postnatal treatment of glucocorticoids with antioxidants may diminish unwanted effects. Methodology/Principal Findings: Male rat pups received a course of dexamethasone (Dex), or Dex with vitamins C and E (DexCE), on postnatal days 1-6 (P1-6). Controls received vehicle (Ctrl) or vehicle with vitamins (CtrlCE) Postnatal Psychological Stress. Each of the three above measures (PSS, STAI, and EPDS) was repeated when offspring were 2-3 years of age to assess postnatal psychological stress. Similar to the prenatal measures, these three scales were combined to create a composite variable representing maternal postnatal psychological stress The present study tested the hypothesis that chronic prenatal ethanol exposure causes long-lasting changes in glucocorticoid signalling in postnatal offspring. Pregnant guinea pigs were treated with ethanol (4 g/kg maternal body weight/day)